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Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene

Disruption of circadian rhythms has been implicated in an increased risk for cancer development. The Period2 (Per2) gene encodes one of the major components of the mammalian circadian clock, which plays a key role in controlling the circadian rhythms in physiology and behavior. PER2 has also been re...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Katamune, Chiharu, Koyanagi, Satoru, Hashikawa, Ken-ichi, Kusunose, Naoki, Akamine, Takahiro, Matsunaga, Naoya, Ohdo, Shigehiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333901/
https://ncbi.nlm.nih.gov/pubmed/30429219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004942
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