RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene

The expression and function of some xenobiotic transporters vary according to the time of the day, causing the dosing time-dependent changes in drug disposition and toxicity. P-glycoprotein (P-gp), encoded by the ABCB1 gene, is highly expressed in the kidneys and functions in the renal elimination o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Omata, Yuji, Yamauchi, Tomoaki, Tsuruta, Akito, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095175/
https://ncbi.nlm.nih.gov/pubmed/33781748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100601
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