RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene

The expression and function of some xenobiotic transporters vary according to the time of the day, causing the dosing time-dependent changes in drug disposition and toxicity. P-glycoprotein (P-gp), encoded by the ABCB1 gene, is highly expressed in the kidneys and functions in the renal elimination o...

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Vydáno v:J Biol Chem
Hlavní autoři: Omata, Yuji, Yamauchi, Tomoaki, Tsuruta, Akito, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095175/
https://ncbi.nlm.nih.gov/pubmed/33781748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100601
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