Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

Disruption of the circadian clock machinery in cancer cells is implicated in tumor malignancy. Studies on cancer therapy reveal the presence of heterogeneous cells, including breast cancer stem-like cells (BCSCs), in breast tumors. BCSCs are often characterized by high aldehyde dehydrogenase (ALDH)...

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Udgivet i:eLife
Main Authors: Ogino, Takashi, Matsunaga, Naoya, Tanaka, Takahiro, Tanihara, Tomohito, Terajima, Hideki, Yoshitane, Hikari, Fukada, Yoshitaka, Tsuruta, Akito, Koyanagi, Satoru, Ohdo, Shigehiro
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102063/
https://ncbi.nlm.nih.gov/pubmed/33890571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66155
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