Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

[Image: see text] Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect. To reduce the potential risk of nonselective covalent modification, molecular design of covalent inhibitors is criticall...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sato, Mami, Fuchida, Hirokazu, Shindo, Naoya, Kuwata, Keiko, Tokunaga, Keisuke, Xiao-Lin, Guo, Inamori, Ryo, Hosokawa, Keitaro, Watari, Kosuke, Shibata, Tomohiro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro, Ono, Mayumi, Ojida, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294701/
https://ncbi.nlm.nih.gov/pubmed/32550993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00574
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados