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VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner

The failure of standard treatment for patients diagnosed with glioblastoma (GBM) coupled with the highly vascularized nature of this solid tumor has led to the consideration of agents targeting VEGF or VEGFRs, as alternative therapeutic strategies for this disease. Despite modest achievements in sur...

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Bibliografiske detaljer
Udgivet i:Cancer Lett
Main Authors: Pham, Kien, Luo, Defang, Siemann, Dietmar W., Law, Brian K., Reynolds, Brent A., Hothi, Parvinder, Foltz, Gregory, Harrison, Jeffrey K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294457/
https://ncbi.nlm.nih.gov/pubmed/25676691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.02.005
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