High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells

Glioblastoma Multiforme (GBM) continues to have a poor patient prognosis despite optimal standard of care. Glioma stem cells (GSCs) have been implicated as the presumed cause of tumor recurrence and resistance to therapy. With this in mind, we screened a diverse chemical library of 2,000 compounds t...

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Detalhes bibliográficos
Main Authors: Hothi, Parvinder, Martins, Timothy J., Chen, LiPing, Deleyrolle, Loic, Yoon, Jae-Geun, Reynolds, Brent, Foltz, Greg
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research: Complementary Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717950/
https://ncbi.nlm.nih.gov/pubmed/23165409
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