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VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner

The failure of standard treatment for patients diagnosed with glioblastoma (GBM) coupled with the highly vascularized nature of this solid tumor has led to the consideration of agents targeting VEGF or VEGFRs, as alternative therapeutic strategies for this disease. Despite modest achievements in sur...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Pham, Kien, Luo, Defang, Siemann, Dietmar W., Law, Brian K., Reynolds, Brent A., Hothi, Parvinder, Foltz, Gregory, Harrison, Jeffrey K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294457/
https://ncbi.nlm.nih.gov/pubmed/25676691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.02.005
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