Cellular Fibronectin Containing Extra Domain A Causes Insulin Resistance via Toll-like Receptor 4

We determined the role of cellular fibronectin (CFN) containing the alternatively spliced extra domain A (FN-EDA) in causing insulin resistance (IR) through toll-like receptor 4 (TLR4). Circulating FN-EDA level was evaluated in mouse and rat IR models. Specific anti-FN-EDA antibody and TLR4 inhibito...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rajak, Sangam, Hussain, Yusuf, Singh, Khushboo, Tiwari, Swasti, Ahmad, Basir, Bharti, Sachi, Prakash, Prem
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272645/
https://ncbi.nlm.nih.gov/pubmed/32499562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65970-6
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