Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here we show that PGE2 caused mitochondrial membrane potential (Δψ(m)) to dissipate in interleukin-4 activated macroph...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Sanin, David E., Matsushita, Mai, Geltink, Ramon I. Klein, Grzes, Katarzyna M., van Teijlingen Bakker, Nikki, Corrado, Mauro, Kabat, Agnieszka M., Buck, Michael D., Qiu, Jing, Lawless, Simon J., Cameron, Alanna M., Villa, Matteo, Baixauli, Francesc, Patterson, Annette E., Hässler, Fabian, Curtis, Jonathan D., O’Neill, Christina M., O’Sullivan, David, Wu, Duojiao, Mittler, Gerhard, Huang, Stanley Ching-Cheng, Pearce, Erika L., Pearce, Edward J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271981/
https://ncbi.nlm.nih.gov/pubmed/30566880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.10.011
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