Triacylglycerol synthesis enhances macrophage inflammatory function

Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in macrophages. Here we explore the basis and significance of this process. Our findings indicate that LD development is...

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Publicado en:Nat Commun
Autores principales: Castoldi, Angela, Monteiro, Lauar B., van Teijlingen Bakker, Nikki, Sanin, David E., Rana, Nisha, Corrado, Mauro, Cameron, Alanna M., Hässler, Fabian, Matsushita, Mai, Caputa, George, Klein Geltink, Ramon I., Büscher, Jörg, Edwards-Hicks, Joy, Pearce, Erika L., Pearce, Edward J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427976/
https://ncbi.nlm.nih.gov/pubmed/32796836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17881-3
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