Acetate Promotes T Cell Effector Function during Glucose Restriction

Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use acetate as a substra...

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Publicat a:Cell Rep
Autors principals: Qiu, Jing, Villa, Matteo, Sanin, David E., Buck, Michael D., O’Sullivan, David, Ching, Reagan, Matsushita, Mai, Grzes, Katarzyna M., Winkler, Frances, Chang, Chih-Hao, Curtis, Jonathan D., Kyle, Ryan L., Van Teijlingen Bakker, Nikki, Corrado, Mauro, Haessler, Fabian, Alfei, Francesca, Edwards-Hicks, Joy, Maggi, Leonard B., Zehn, Dietmar, Egawa, Takeshi, Bengsch, Bertram, Klein Geltink, Ramon I., Jenuwein, Thomas, Pearce, Edward J., Pearce, Erika L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544383/
https://ncbi.nlm.nih.gov/pubmed/31091446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.04.022
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