Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism

Optic atrophy 1 (OPA1), a mitochondria-shaping protein controlling cristae biogenesis and respiration, is required for memory T cell function, but whether it affects intrathymic T cell development is unknown. Here we show that OPA1 is necessary for thymocyte maturation at the double negative (DN)3 s...

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Vydáno v:Cell Death Differ
Hlavní autoři: Corrado, Mauro, Samardžić, Dijana, Giacomello, Marta, Rana, Nisha, Pearce, Erika L., Scorrano, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257785/
https://ncbi.nlm.nih.gov/pubmed/33649469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-021-00747-6
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