Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here we show that PGE2 caused mitochondrial membrane potential (Δψ(m)) to dissipate in interleukin-4 activated macroph...

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Veröffentlicht in:Immunity
Hauptverfasser: Sanin, David E., Matsushita, Mai, Geltink, Ramon I. Klein, Grzes, Katarzyna M., van Teijlingen Bakker, Nikki, Corrado, Mauro, Kabat, Agnieszka M., Buck, Michael D., Qiu, Jing, Lawless, Simon J., Cameron, Alanna M., Villa, Matteo, Baixauli, Francesc, Patterson, Annette E., Hässler, Fabian, Curtis, Jonathan D., O’Neill, Christina M., O’Sullivan, David, Wu, Duojiao, Mittler, Gerhard, Huang, Stanley Ching-Cheng, Pearce, Erika L., Pearce, Edward J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271981/
https://ncbi.nlm.nih.gov/pubmed/30566880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.10.011
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