Dynamic Cardiolipin Synthesis Is Required for CD8(+) T Cell Immunity

Mitochondria constantly adapt to the metabolic needs of a cell. This mitochondrial plasticity is critical to T cells, which modulate metabolism depending on antigen-driven signals and environment. We show here that de novo synthesis of the mitochondrial membrane-specific lipid cardiolipin maintains...

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Publicado en:Cell Metab
Main Authors: Corrado, Mauro, Edwards-Hicks, Joy, Villa, Matteo, Flachsmann, Lea J., Sanin, David E., Jacobs, Maaike, Baixauli, Francesc, Stanczak, Michal, Anderson, Eve, Azuma, Mai, Quintana, Andrea, Curtis, Jonathan D., Clapes, Thomas, Grzes, Katarzyna M., Kabat, Agnieszka M., Kyle, Ryan, Patterson, Annette E., Geltink, Ramon Klein, Amulic, Borko, Steward, Colin G., Strathdee, Douglas, Trompouki, Eirini, O’Sullivan, David, Pearce, Edward J., Pearce, Erika L.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721104/
https://ncbi.nlm.nih.gov/pubmed/33264603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.11.003
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