In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors

Leishmania major is the causative agent of cutaneous leishmaniasis (CL). No human vaccine is available for CL, and current drug regimens present several drawbacks, such as emerging resistance, severe toxicity, medium effectiveness, and/or high cost. Thus, the need for better treatment options agains...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Rodriguez, Felipe, John, Sarah F., Iniguez, Eva, Montalvo, Sebastian, Michael, Karina, White, Lyndsey, Liang, Dong, Olaleye, Omonike A., Maldonado, Rosa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269496/
https://ncbi.nlm.nih.gov/pubmed/32179532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01422-19
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