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Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

INTRODUCTION: CLBQ14, a derivative of 8-hydroxyquinoline, exerts its chemotherapeutic effect by inhibiting methionine aminopeptidase (MetAP), the enzyme responsible for the post-translational modification of several proteins and polypeptides. MetAP is a novel target for infectious diseases. CLBQ14 i...

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Publicado no:Drug Des Devel Ther
Main Authors: Ekpenyong, Oscar, Gao, Xiuqing, Ma, Jing, Cooper, Candace, Nguyen, Linh, Olaleye, Omonike A, Liang, Dong, Xie, Huan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127848/
https://ncbi.nlm.nih.gov/pubmed/32280198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S238148
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