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Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases

Our previous target validation studies established that inhibition of methionine aminopeptidases (MtMetAP, type 1a and 1c) from Mycobacterium tuberculosis (Mtb) is an effective approach to suppressing Mtb growth in culture. A novel class of MtMetAP1c inhibitors comprising of N'-hydroxy-N-(4H,5H...

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Detalhes bibliográficos
Main Authors: Bhat, Shridhar, Olaleye, Omonike, Meyer, Kirsten J., Shi, Wanliang, Zhang, Ying, Liu, Jun O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495175/
https://ncbi.nlm.nih.gov/pubmed/22704656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.022
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