Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets

Methionine aminopeptidase (MetAP) is a metalloprotease that removes the N-terminal methionine during protein synthesis. To assess the importance of the two MetAPs in M. tuberculosis, we overexpressed and purified each of the MetAPs to near homogeneity and showed that both were active as MetAP enzyme...

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Hlavní autoři: Olaleye, Omonike, Raghunand, Tirumalai R., Bhat, Shridhar, He, Jian, Tyagi, Sandeep, Lamichhane, Gyanu, Gu, Peihua, Zhou, Jiangbing, Zhang, Ying, Grosset, Jacques, Bishai, William R., Liu, Jun O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165048/
https://ncbi.nlm.nih.gov/pubmed/20142044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.12.014
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