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A Simple, Sensitive and Reliable LC-MS/MS Method for the Determination of 7-bromo-5-chloroquinolin-8-ol (CLBQ14), A Potent and Selective Inhibitor of Methionine Aminopeptidases: Application to Pharmacokinetic Studies.

CLBQ14 is an 8-hydroxyquinoline analogue that inhibits methionine aminopeptidase (MetAP), an enzyme responsible for the post-translational modification of several proteins and polypeptides. MetAP has been validated as druggable target for some infectious diseases, and its inhibitors have been invest...

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Bibliografski detalji
Izdano u:J Chromatogr B Analyt Technol Biomed Life Sci
Glavni autori: Ekpenyong, Oscar, Cooper, Candace, Ma, Jing, Liang, Dong, Olaleye, Omonike, Xie, Huan
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6163080/
https://ncbi.nlm.nih.gov/pubmed/30199748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2018.08.027
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