Evaluation of α,β-Unsaturated Ketones as Antileishmanial Agents

In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC(50)], 456 nM, 1,122 nM, and 20 nM, respectively) and intracellular (EC(50), 1...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Vasquez, Miguel A., Iniguez, Eva, Das, Umashankar, Beverley, Stephen M., Herrera, Linda J., Dimmock, Jonathan R., Maldonado, Rosa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432202/
https://ncbi.nlm.nih.gov/pubmed/25801571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04056-14
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