Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation

BACKGROUND: PTEN, a syndromic autism spectrum disorder (ASD) risk gene, is mutated in approximately 10% of macrocephalic ASD cases. Despite the described genetic association between PTEN and ASD and ensuing studies, we continue to have a limited understanding of how PTEN disruption drives ASD pathog...

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Gepubliceerd in:Mol Autism
Hoofdauteurs: Kang, Shin Chung, Jaini, Ritika, Hitomi, Masahiro, Lee, Hyunpil, Sarn, Nick, Thacker, Stetson, Eng, Charis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268763/
https://ncbi.nlm.nih.gov/pubmed/32487265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00337-2
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