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Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity

BACKGROUND: Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the function of...

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Detalhes bibliográficos
Publicado no:Mol Autism
Main Authors: Sarn, Nick, Thacker, Stetson, Lee, Hyunpil, Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176582/
https://ncbi.nlm.nih.gov/pubmed/34088332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-021-00448-4
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