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Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder
There is a strong genetic association between germline PTEN mutation and autism spectrum disorder (ASD), making Pten-mutant models exemplary for the study of ASD pathophysiology. We developed the Pten(m3m4) mouse, where Pten is largely restricted from the nucleus, which recapitulates patient-like, a...
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| Publicado no: | Transl Psychiatry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6341090/ https://ncbi.nlm.nih.gov/pubmed/30664625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0364-7 |
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