Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype

Germline mutations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macrocephaly. To explore the importance of nuclear PTEN in the development of ASD and macrocephaly, we previously generated a mouse model with predominantly cytoplasmic localization of Pten (Pten(m...

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Vydáno v:Mol Psychiatry
Hlavní autoři: Sarn, Nicholas, Jaini, Ritika, Thacker, Stetson, Lee, Hyunpil, Dutta, Ranjan, Eng, Charis
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159731/
https://ncbi.nlm.nih.gov/pubmed/32055008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0681-0
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