Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 atten...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Cheteh, Emarndeena H., Sarne, Victoria, Ceder, Sophia, Bianchi, Julie, Augsten, Martin, Rundqvist, Helene, Egevad, Lars, Östman, Arne, Wiman, Klas G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265343/
https://ncbi.nlm.nih.gov/pubmed/32528731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0272-5
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