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Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 atten...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Death Discov
Κύριοι συγγραφείς: Cheteh, Emarndeena H., Sarne, Victoria, Ceder, Sophia, Bianchi, Julie, Augsten, Martin, Rundqvist, Helene, Egevad, Lars, Östman, Arne, Wiman, Klas G.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2020
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265343/
https://ncbi.nlm.nih.gov/pubmed/32528731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0272-5
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