Formation of ultralong DH regions through genomic rearrangement

BACKGROUND: Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding over 50 amino acids. Many bovine IGHD regions have sequence similar...

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Bibliographic Details
Published in:BMC Immunol
Main Authors: Smider, Brevin A., Smider, Vaughn V.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265228/
https://ncbi.nlm.nih.gov/pubmed/32487018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-020-00359-8
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