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Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies

A subset of bovine antibodies have an exceptionally long third heavy-chain complementarity determining region (CDR H3) that is highly variable in sequence and includes multiple cysteines. These long CDR H3s (up to 69 residues) fold into a long stalk atop which sits a knob domain that is located far...

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Pubblicato in:Sci Immunol
Autori principali: Stanfield, Robyn L., Wilson, Ian A., Smider, Vaughn V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000368/
https://ncbi.nlm.nih.gov/pubmed/27574710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf7962
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