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Diversity in the Cow Ultralong CDR H3 Antibody Repertoire

Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob” structure, with the knob protruding far out of the an...

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Pubblicato in:Front Immunol
Autori principali: Haakenson, Jeremy K., Huang, Ruiqi, Smider, Vaughn V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994613/
https://ncbi.nlm.nih.gov/pubmed/29915599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01262
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