Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies

The antibody repertoire of Bos taurus is characterized by a subset of variable heavy (VH) chain regions with ultralong third complementarity determining regions (CDR3) which, compared to other species, can provide a potent response to challenging antigens like HIV env. These unusual CDR3 can range t...

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Vydáno v:Cell Mol Immunol
Hlavní autoři: Deiss, Thaddeus C, Vadnais, Melissa, Wang, Feng, Chen, Patricia L, Torkamani, Ali, Mwangi, Waithaka, Lefranc, Marie-Paule, Criscitiello, Michael F, Smider, Vaughn V
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318308/
https://ncbi.nlm.nih.gov/pubmed/29200193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2017.117
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