In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients

PURPOSE: To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2-hydroxyglutarate (2HG) production between the preclinical model and patients. METHODS: Five patient-derived xenograft (PDX) mice were...

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Pubblicato in:Magn Reson Med
Autori principali: Tiwari, Vivek, Mashimo, Tomoyuki, An, Zhongxu, Vemireddy, Vamsidhara, Piccirillo, Sara, Askari, Pegah, Hulsey, Keith M., Zhang, Shanrong, de Graaf, Robin A., Patel, Toral R., Pan, Edward, Mickey, Bruce E., Maher, Elizabeth A., Bachoo, Robert M., Choi, Changho
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263951/
https://ncbi.nlm.nih.gov/pubmed/32003035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.28183
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