New codons for efficient production of unnatural proteins in a semi-synthetic organism

Natural organisms use a four-letter genetic alphabet that makes available 64 triplet codons, of which 61 are sense codons used to encode proteins with the 20 canonical amino acids. We have shown that the unnatural nucleotides dNaM and dTPT3 pair to form an unnatural base pair (UBP) and allow for the...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Fischer, Emil C., Hashimoto, Koji, Zhang, Yorke, Feldman, Aaron W., Dien, Vivian T., Karadeema, Rebekah J., Adhikary, Ramkrishna, Ledbetter, Michael P., Krishnamurthy, Ramanarayanan, Romesberg, Floyd E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263176/
https://ncbi.nlm.nih.gov/pubmed/32251411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0507-z
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