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In Vivo Structure-Activity Relationships and Optimization of an Unnatural Base Pair for Replication in a Semi-Synthetic Organism

In an effort to expand the genetic alphabet and create semi-synthetic organisms (SSOs) that store and retrieve increased information, we have developed the unnatural base pairs (UBPs) dNaM and d5SICS or dTPT3 (dNaM-d5SICS and dNaM-dTPT3). The UBPs form based on hydrophobic and packing forces, as opp...

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Pubblicato in:J Am Chem Soc
Autori principali: Feldman, Aaron W., Romesberg, Floyd E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603228/
https://ncbi.nlm.nih.gov/pubmed/28796508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b03540
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