Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2

The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in MAGI2. Here, we show that MAGI2 forms a complex wi...

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Bibliografiske detaljer
Udgivet i:Kidney Int
Main Authors: Zhu, Bingbing, Cao, Aili, Li, Jianhua, Young, James, Wong, Jenny, Ashraf, Shazia, Bierzynska, Agnieszka, Menon, Madhav C., Hou, Steven, Sawyers, Charles, Campbell, Kirk N., Saleem, Moin A., He, John C., Hildebrandt, Friedhelm, D’Agati, Vivette D., Peng, Wen, Kaufman, Lewis
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259463/
https://ncbi.nlm.nih.gov/pubmed/31171376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.03.016
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