RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis

RapGEF2 is one of many guanine nucleotide exchange factors (GEFs) that specifically activate Rap1. Here, we generated RapGEF2 conditional knockout mice and studied its role in embryogenesis and fetal as well as adult hematopoietic stem cell (HSC) regulation. RapGEF2 deficiency led to embryonic letha...

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Bibliografiska uppgifter
Huvudupphovsmän: Satyanarayana, Ande, Gudmundsson, Kristbjorn Orri, Chen, Xiu, Coppola, Vincenzo, Tessarollo, Lino, Keller, Jonathan R., Hou, Steven X.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2010
Ämnen:
Hematopoiesis and Stem Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974602/
https://ncbi.nlm.nih.gov/pubmed/20595512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-262964
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