RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis

RapGEF2 is one of many guanine nucleotide exchange factors (GEFs) that specifically activate Rap1. Here, we generated RapGEF2 conditional knockout mice and studied its role in embryogenesis and fetal as well as adult hematopoietic stem cell (HSC) regulation. RapGEF2 deficiency led to embryonic letha...

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Autors principals: Satyanarayana, Ande, Gudmundsson, Kristbjorn Orri, Chen, Xiu, Coppola, Vincenzo, Tessarollo, Lino, Keller, Jonathan R., Hou, Steven X.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974602/
https://ncbi.nlm.nih.gov/pubmed/20595512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-262964
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