MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes

MAGI-1 is a multidomain cytosolic scaffolding protein that in the kidney is specifically located at the podocyte slit diaphragm, a specialized junction that is universally injured in proteinuric diseases. There it interacts with several essential molecules, including nephrin and neph1, which are req...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Ni, Jie, Bao, Sujin, Johnson, Ruth I., Zhu, Bingbing, Li, Jianhua, Vadaparampil, Justin, Smith, Christopher M., Campbell, Kirk N, Grahammer, Florian, Huber, Tobias B., He, John C., D'Agati, Vivette D., Chan, Andrew, Kaufman, Lewis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114397/
https://ncbi.nlm.nih.gov/pubmed/27707879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745026
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