Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2

The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in MAGI2. Here, we show that MAGI2 forms a complex wi...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Zhu, Bingbing, Cao, Aili, Li, Jianhua, Young, James, Wong, Jenny, Ashraf, Shazia, Bierzynska, Agnieszka, Menon, Madhav C., Hou, Steven, Sawyers, Charles, Campbell, Kirk N., Saleem, Moin A., He, John C., Hildebrandt, Friedhelm, D’Agati, Vivette D., Peng, Wen, Kaufman, Lewis
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259463/
https://ncbi.nlm.nih.gov/pubmed/31171376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.03.016
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