Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2

The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in MAGI2. Here, we show that MAGI2 forms a complex wi...

詳細記述

保存先:
書誌詳細
出版年:Kidney Int
主要な著者: Zhu, Bingbing, Cao, Aili, Li, Jianhua, Young, James, Wong, Jenny, Ashraf, Shazia, Bierzynska, Agnieszka, Menon, Madhav C., Hou, Steven, Sawyers, Charles, Campbell, Kirk N., Saleem, Moin A., He, John C., Hildebrandt, Friedhelm, D’Agati, Vivette D., Peng, Wen, Kaufman, Lewis
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259463/
https://ncbi.nlm.nih.gov/pubmed/31171376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.03.016
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