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Insulin and epidermal growth factor receptor family members share parallel activation mechanisms

Insulin receptor (IR) and the epidermal growth factor receptor (EGFR) were the first receptor tyrosine kinases (RTKs) to be studied in detail. Both are important clinical targets—in diabetes and cancer, respectively. They have unique extracellular domain compositions among RTKs, but share a common m...

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Bibliografische gegevens
Gepubliceerd in:Protein Sci
Hoofdauteurs: Ferguson, Kathryn M., Hu, Chun, Lemmon, Mark A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255510/
https://ncbi.nlm.nih.gov/pubmed/32297376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3871
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