Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

The initiation of epidermal growth factor receptor (EGFR) kinase activity proceeds via an asymmetric dimerization mechanism in which a “donor” tyrosine kinase domain (TKD) contacts an “acceptor” TKD, leading to its activation. In the context of a ligand-induced dimer, identical wild-type EGFR TKDs a...

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Main Authors: Red Brewer, Monica, Yun, Cai-Hong, Lai, Darson, Lemmon, Mark A., Eck, Michael J., Pao, William
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780914/
https://ncbi.nlm.nih.gov/pubmed/24019492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220050110
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