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Mechanism for activation of mutated epidermal growth factor receptors in lung cancer
The initiation of epidermal growth factor receptor (EGFR) kinase activity proceeds via an asymmetric dimerization mechanism in which a “donor” tyrosine kinase domain (TKD) contacts an “acceptor” TKD, leading to its activation. In the context of a ligand-induced dimer, identical wild-type EGFR TKDs a...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780914/ https://ncbi.nlm.nih.gov/pubmed/24019492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220050110 |
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