Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but its function in the adult brain remains not well understood. In this study, we identify NLK as an interactor of huntingtin protein (HTT). We report that NLK levels are significantly dec...

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發表在:Hum Mol Genet
Main Authors: Jiang, Mali, Zhang, Xiaoyan, Liu, Hongshuai, LeBron, Jared, Alexandris, Athanasios, Peng, Qi, Gu, Hao, Yang, Fanghan, Li, Yuchen, Wang, Ruiling, Hou, Zhipeng, Arbez, Nicolas, Ren, Qianwei, Dong, Jen-Li, Whela, Emma, Wang, Ronald, Ratovitski, Tamara, Troncoso, Juan C, Mori, Susumu, Ross, Christopher A, Lim, Janghoo, Duan, Wenzhen
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254850/
https://ncbi.nlm.nih.gov/pubmed/32242231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa061
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