Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but its function in the adult brain remains not well understood. In this study, we identify NLK as an interactor of huntingtin protein (HTT). We report that NLK levels are significantly dec...

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Pubblicato in:Hum Mol Genet
Autori principali: Jiang, Mali, Zhang, Xiaoyan, Liu, Hongshuai, LeBron, Jared, Alexandris, Athanasios, Peng, Qi, Gu, Hao, Yang, Fanghan, Li, Yuchen, Wang, Ruiling, Hou, Zhipeng, Arbez, Nicolas, Ren, Qianwei, Dong, Jen-Li, Whela, Emma, Wang, Ronald, Ratovitski, Tamara, Troncoso, Juan C, Mori, Susumu, Ross, Christopher A, Lim, Janghoo, Duan, Wenzhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254850/
https://ncbi.nlm.nih.gov/pubmed/32242231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa061
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