Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington’s disease

Huntington’s disease (HD) is caused by a cytosine-adenine-guanine (CAG) trinucleotide repeat expansion in the huntingtin (HTT) gene encoding an elongated polyglutamine tract within the N-terminal of the huntingtin protein (Htt) and leads to Htt misfolding, aberrant protein aggregation, and progressi...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Hum Mol Genet
Autors principals: Zhou, Xiao, Li, Gang, Kaplan, Anna, Gaschler, Michael M, Zhang, Xiaoyan, Hou, Zhipeng, Jiang, Mali, Zott, Roseann, Cremers, Serge, Stockwell, Brent R, Duan, Wenzhen
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905666/
https://ncbi.nlm.nih.gov/pubmed/29462355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy061
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars