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Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective
Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmic reticulum that is up-regulated in mouse models of, and brains of patients with, neurodegenerative diseases involving protein misfolding. PDI’s role in these diseases, however, is not fully understood. Here, we report the dis...
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| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418888/ https://ncbi.nlm.nih.gov/pubmed/25848045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500439112 |
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