Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmic reticulum that is up-regulated in mouse models of, and brains of patients with, neurodegenerative diseases involving protein misfolding. PDI’s role in these diseases, however, is not fully understood. Here, we report the dis...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Kaplan, Anna, Gaschler, Michael M., Dunn, Denise E., Colligan, Ryan, Brown, Lewis M., Palmer, Arthur G., Lo, Donald C., Stockwell, Brent R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418888/
https://ncbi.nlm.nih.gov/pubmed/25848045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500439112
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