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CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)–based carrier for delivery of Cas12a/CRISP...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Sun, Wujin, Wang, Jinqiang, Hu, Quanyin, Zhou, Xingwu, Khademhosseini, Ali, Gu, Zhen
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239642/
https://ncbi.nlm.nih.gov/pubmed/32490205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2983
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