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CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation
CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)–based carrier for delivery of Cas12a/CRISP...
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| Publié dans: | Sci Adv |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Association for the Advancement of Science
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7239642/ https://ncbi.nlm.nih.gov/pubmed/32490205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2983 |
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