CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)–based carrier for delivery of Cas12a/CRISP...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Adv
Egile Nagusiak: Sun, Wujin, Wang, Jinqiang, Hu, Quanyin, Zhou, Xingwu, Khademhosseini, Ali, Gu, Zhen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239642/
https://ncbi.nlm.nih.gov/pubmed/32490205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba2983
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