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Efficient Delivery of CRISPR-Cas9 for Genome Editing via Self-Assembled DNA Nanoclews()
CRISPR-Cas9 represents a promising technology for genome editing, yet means of safe and efficient delivery remain to be fully realized. Here, we report a novel delivery vehicle to deliver the Cas9 protein and single-guide RNA simultaneously based on DNA nanoclews, yarn-like DNA nanoparticles synthes...
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| Publié dans: | Angew Chem Int Ed Engl |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677991/ https://ncbi.nlm.nih.gov/pubmed/26310292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506030 |
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