Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

[Image: see text] Starting from known GLI1 inhibitors, a pharmacophore-based virtual screening approach was applied to databases of commercially available compounds with the aim of identifying new GLI1 modulators. As a result, three different chemical scaffolds emerged that were characterized by a s...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Manetti, Fabrizio, Stecca, Barbara, Santini, Roberta, Maresca, Luisa, Giannini, Giuseppe, Taddei, Maurizio, Petricci, Elena
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236221/
https://ncbi.nlm.nih.gov/pubmed/32435392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00639
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