Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe

Aberrant activation of the Hedgehog (HH) signaling is a critical driver in tumorigenesis. The Smoothened (SMO) receptor is one of the major upstream transducers of the HH pathway and a target for the development of anticancer agents. The SMO inhibitor Vismodegib (GDC-0449/Erivedge) has been approved...

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Vydáno v:Cell Death Dis
Hlavní autoři: Pietrobono, Silvia, Santini, Roberta, Gagliardi, Sinforosa, Dapporto, Francesca, Colecchia, David, Chiariello, Mario, Leone, Cosima, Valoti, Massimo, Manetti, Fabrizio, Petricci, Elena, Taddei, Maurizio, Stecca, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833413/
https://ncbi.nlm.nih.gov/pubmed/29396391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0142-0
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